The partnership between BMD and you will lbs are stronger than ranging from Body mass index and BMD

The partnership between BMD and you will lbs are stronger than ranging from Body mass index and BMD

3.3. Chance Issues

Compared with men with BMI? 25 kg/m 2 , the age-adjusted risk of osteoporosis was over four-fold higher in those with BMI < 25 (odds ratio (OR) 4.4 (1.51, ) in age-adjusted model (Table 3). The association between BMI and osteopenia was similar among overweight/obese and normal weight men, although not statistically significant (Table 3).

One another Body mass index and you will weight was indeed synchronised that have BMD, and you may BMC indicators and most powerful Pearson’s correlation coefficients was indeed found between weight and BMC in total cool and you can trochanter regions and you will this new weakest of them was in fact anywhere between Bmi and femoral neck BMC. The fresh correlations between ages and you can BMD and BMC indicators was bad (Table cuatro).

The age-adjusted ratio away from BMD and BMC type explained of the Bmi and you will pounds is revealed from inside the Desk 5. Pounds tended to let you know higher variations in BMD and BMC delivery at all the studied skeletal sites versus Bmi. This is shown by the steeper slope (?) of your own particular linear regression traces. The number one difference between BMD and BMC shipment looked from the trochanter BMC followed by lumbar BMC to possess weight. Lbs is an important predictor out-of BMD and you may BMC variation in old Iranian men.

4. Discussion

In this study, both BMI and weight were associated with BMD, and obesity significantly decreased the risk for osteoporosis in men. These results are consistent with most previous studies, particularly in postmenopausal women, which indicated that lower BMI and weight were associated with lower BMD. Prospective studies found that the early postmenopausal women who have low BMI lose more bones compared to those with higher BMI tertiles [4, 8]. In other cross-sectional studies, however, thinness is related to both osteoporosis and increased fracture risk [10, 11]. Iqbal et al. found that low BMI is a good indicator for referral of women less than 60 years old for measurements of BMD. Similar studies also reported a consistent finding that lower BMI was associated with lower BMD [5, 6, 28]. In a study similar to ours, those with lower BMI were at higher risk of low BMD . The Studies of National Osteoporosis Foundation and others suggested that low BMI should be included in the risk assessment tools for evaluation of osteoporosis and osteoporotic fracture risk [29–31]. We found that men with BMI < 25 had 4.4 (95% CI 1.5, 12.8) times higher age-adjusted risk of osteoporosis than men with BMI ? 25. In contrast, Steinschneider et al. in a cross-sectional study reported that the correlation between BMD at the femoral neck and BMI was highly positive among postmenopausal women. A hospital-based study conducted in elderly men reported that overweight and obese men were more likely to have osteoporosis and osteopenia . The possible explanation for the discrepancies between these results might be related to populations, research designs, sampling methods, and methodological differences.

The latest elements by which fatty tissue exerts positive effects towards the BMD position are not completely clear. The brand new putative process significance regarding fatty tissue getting skeletal stability probably resides in the fresh character of several adipokines into the bone renovations courtesy impact on each other creation and you will resorption. Has just, limbs might have been sensed a keen hormonal organ affecting pounds handle and sugar homoeostasis through the steps away from bones-derived affairs such as osteocalcin and you will osteopontin [23, 34–36]. This new putative crosstalk anywhere between lbs additionally the bones comprises a good homoeostatic opinions program where adipokines black dating sites and you will particles secreted because of the osteoblasts and you will osteoclasts show the link from an active bone-adipose axis [34–36]. Obesity is also with the BMD by conversion process of androgen so you can estrogen , and therefore improves limbs mass in both visitors [38, 39] and you can holds match plasma levels of insulin and controlling issues plus insulin-particularly progress foundation-1, leptin, and you may adiponectin . At the same time, carrying excess fat will bring padding towards the cool in case there is a beneficial fall . Although not, the new mechanisms in which each one of these events are present remain not sure.

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